Considering That Covid-19 first ended up being a harmful pandemic, numerous have actually questioned how marijuana use may factor into danger or healing for the fatal disease. While some instantly presumed cannabis was damaging, like tobacco, and others assumed it could cure or prevent the illness, researchers quickly started to explore the question.
Early research concentrated on the cannabinoid CBD as a possible treatment for cytokine storms and severe breathing distress syndrome (ARDS) – a sign in serious cases of Covid-19, which can lead to death. The results suggested that CBD may be a reliable treatment, although human studies need to be carried out to verify.
Now, scientists are exploring whether another popular cannabinoid, THC, may assist with treating the novel coronavirus. And they recommend THC may actually have the ability to prevent Covid-19 from intensifying into a fatal condition.
The brand-new research study from the University of South Carolina, Columbia examined whether utilizing THC might be able to avoid Covid-19 deaths.
In this case, scientists were looking to see if THC’s anti-inflammatory powers might be able to combat against cytokine storms and ARDS.
Cytokine storms are a hazardous sign of Covid-19(and other extreme infections) which takes place when the body immune system goes overboard in its effort to combat off an infection. Cytokines are typically part of a healthy immune response – triggering inflammation to combat against an infection. When the infection is severe enough, our bodies can launch way too numerous cytokines, and thus create an unsafe level of swelling. This leads to ARDS, where breathing ends up being difficult or perhaps impossible. And cytokine storms can likewise lead to death from organ failure.
Several studies point to CBD as a potential treatment for ARDS, and the FDA just recently greenlighted medical trials for an artificial cannabinoid treatment for ARDS.
In the brand-new research, researchers checked out whether THC might be able to treat cytokine storms and ARDS, by studying its results on mice
In this animal design, scientists exposed two groups of healthy mice to a bacterial infection called Staphylococcus aureus or SEB. SEB is known to trigger cytokine storms and ARDS in mice, and it usually results in death for those exposed. In this case, however, the researchers offered one group of mice a treatment of THC right after they infected them with SEB, in addition to doses 24 and 48 hours later.
Incredibly, 100%of the mice who were given THC before being infected endured having SEB. On the other hand, 100%of the mice who weren’t given THC died from the ARDS that resulted from their infection.
While some scientists recommended early on that cannabis’ anti-inflammatory impacts might potentially be unsafe in early phases of an infection – reducing the immune system when it ought to be protecting versus attack.
Researchers likewise discovered that THC was also able to considerably suppress the inflammatory cytokines that are included with ARDS. It likewise had the ability to raise regulative T cells which assist reduce inflammation. Interestingly, researchers likewise noticed a shift in the expression of miRNA in cells in the lungs – which might play a crucial function in suppressing cytokine storms, minimizing lung injury and preventing death from ARDS.
In a follow up study, the same scientists went an action further, checking out whether the results from the first research study are pertinent to those suffering from ARDS as an outcome of Covid-19
The scientists explain that “Jointly, this study suggests that the activation of cannabinoid receptors may function as a therapeutic technique to deal with ARDS associated with Covid-19”
While this is a very early research study, and more research studies must be conducted in human populations with Covid-19, the research suggests that cannabis’ active component THC might be able to avoid Covid-19 from intensifying to ARDS – or treat it if it does.